Publications

 
 

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Du Y-L, Alkhalaf LM, Ryan KS (2015) “In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis for oxazolinone assembly” PNAS, 112(9): 2717-2722. Alkhalaf LM, Ryan KS (2015) “Biosynthetic manipulation of tryptophan in bacteria: pathways and mechanisms” Chem. Biol. 22(3): 317-328. Du Y-L, Ryan KS (2015) “Expansion of bisindole biosynthetic pathways by combinatorial construction” ACS Synthetic Biology, 6(4):682-688. Du Y-L, Williams DE, Patrick BO, Andersen RJ, Ryan KS (2014) “Reconstruction of cladoniamide biosynthesis reveals nonenzymatic routes to bisindole diversity” ACS Chem. Biol. 9(12): 2748-2754. Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzales DJ, Nizet V, Dorrestein PC, Moore BS (2014) “Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A” PNAS 11: 1957-62. Du Y-L, Dalisay S, Andersen RJ, Ryan KS (2013) “N-Carbamoylation of 2,4-diaminobutyrate reroutes the outcome in padanamide biosynthesis” Chem. Biol. 20: 1002-11.Publications_files/proof.pdf

Du Y-L, Ding T, Patrick BO, Ryan KS (2013) “Xenocladoniamide F, minimal indolotryptoline from the cladoniamide pathway” Tetrahedron Lett., in press.


Du Y-L, Ding T, Ryan KS (2013) “Biosynthetic O-methylation protects cladoniamides from self-destruction” Org. Lett., 15: 2538-2541.


Sydor AM, Jost M, Ryan KS, Turo KE, Douglas CD, Drennan CL, Zamble DB (2013) “Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases” Biochemistry 52: 1788-1801.


Goldman P,* Ryan KS,* Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL (2012) “An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes” Chem. Biol., 19: 855-865. *Equal contributors.

     Preview by Shiou-Chuan Tsai: “Babysitting flavin for                                    biosynthesis”


Yamanaka Y, Ryan KS, Gulder TAM, Hughes CC, Moore BS (2012) “Flavoenzyme-catalyzed atroposelective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis”    J. Am. Chem. Soc., 134: 12434-12437.


Davies J, Ryan KS (2012) “Introducing the parvome: bioactive compounds in the microbial world” ACS Chem. Biol., 7: 252-259.


Ryan KS (2011) "Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold" PLoS ONE, 6: e23694.


Roberts AA,* Ryan KS,* Moore BS, Gulder TA (2010) “Total (bio)synthesis: strategies.  of chemists and of nature” Top. Curr. Chem., 297: 149-203. *Equal contributors.


Ryan KS, Moore BS (2009) “Alkaloid biosynthesis takes root” Nat. Chem. Biol., 5: 140-141.


Ryan KS, Drennan CL (2009) “Divergent pathways in the biosynthesis of bisindole natural products” Chem. Biol., 16: 351-364.


Ryan KS, Chakraborty S, Howard-Jones AR, Walsh CT, Ballou DP, Drennan CL (2008) “The FAD cofactor of RebC shifts to an IN conformation upon flavin reduction” Biochemistry , 47: 13506-13513.


Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL (2008) “The violacein biosynthetic enzyme VioE shares a fold with lipoprotein transporter proteins” J. Biol. Chem., 283: 6467-6475.


Ryan KS, Howard-Jones AR, Hamill MJ, Elliott SJ, Walsh CT, Drennan CL (2007) “Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC” Proc. Natl. Acad. Sci. U.S.A., 104: 15311-15316.

    Preview by David Ballou:  “Crystallography gets the jump on the enzymologists”


Reiss BD, Mao C, Solis DJ, Ryan KS, Thomson T, Belcher AM (2004) “Biological routes to metal alloy ferromagnetic nanostructures” Nano Lett., 4: 1127-1132.


Malamy JE, Ryan KS (2001) “Environmental regulation of lateral root initiation in Arabidopsis” Plant Physiol., 127: 899-909.