Publications:

Kwan DH, Constantinescu I, Chapanian R, Higgins MA, Kötzler MP, Samain E, Boraston AB, Kizhakkedathu JN, Withers SG (2015) Toward efficient enzymes for the generation of universal blood through structure-guided directed evolution. J Am Chem Soc. 137(17):5695-705.

Shewell LK, Harvey RM, Higgins MA, Day CJ, Hartley-Tassell LE, Chen AY, Gillen CM, James DB, Alonzo F 3rd, Torres VJ, Walker MJ, Paton AW, Paton JC, Jennings MP (2014) The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity. Proc Natl Acad Sci U S A 111(49):E5312-20.

Singh AK, Pluvinage B, Higgins MA, Dalia AB, Woodiga SA, Flynn M, Lloyd AR, Weiser JN, Stubbs KA, Boraston AB, King SJ (2014) Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae β-galactosidase, BgaA. PLoS Pathog. 10(9):e1004364.

Higgins MA, Suits MD, Marsters C, Boraston AB (2014) Structural and functional analysis of fucose-processing enzymes from Streptococcus pneumoniae. J Mol Biol. 426(7):1469-82.

Higgins MA, Boraston AB (2011) Structure of the fucose mutarotase from Streptococcus pneumoniae in complex with L-fucose. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67(Pt 12):1524-30.

Pluvinage B, Higgins MA, Abbott DW, Robb C, Dalia AB, Deng L, Weiser JN, Parsons TB, Fairbanks AJ, Vocadlo DJ, Boraston AB (2011) Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis.

Structure. 19(11):1603-14.

Higgins MA, Ficko-Blean E, Meloncelli PJ, Lowary TL, Boraston AB (2011) The overall architecture and receptor binding of pneumococcal carbohydrate-antigen-hydrolyzing enzymes. J Mol Biol. 411(5):1017-36.

Lammerts van Bueren A, Ficko-Blean E, Pluvinage B, Hehemann JH, Higgins MA, Deng L, Ogunniyi AD, Stroeher UH, El Warry N, Burke RD, Czjzek M, Paton JC, Vocadlo DJ, Boraston AB (2011) The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure. 19(5):640-51.

Batra J, Nagle CM, OMara T, Higgins MA, Dong Y, Tan OL, Lose F, Skeie LM, Srinivasan S, Bolton KL, Song H, Ramus SJ, Gayther SA, Pharoah PDP, Kedda MA, Spurdle AB, Clements JA. (2011) A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival. BMC Cancer. 11:119.

Abbott DW, Higgins MA, Hyrnuik S, Pluvinage B, Lammerts van Bueren A, Boraston AB (2010) The molecular basis of glycogen breakdown and transport in Streptococcus pneumoniae. Mol Microbiol. 77(1):183-99.

Higgins MA, Whitworth GE, El Warry N, Randriantsoa M, Samain E, Burke RD, Vocadlo DJ, Boraston AB. (2009) Differential recognition and hydrolysis of host carbohydrate antigens by Streptococcus pneumoniae family 98 glycoside hydrolases. J Biol Chem. 2009 Sep 18;284(38):26161-73.

Higgins MA, Abbott DW, Boulanger MJ, Boraston AB. (2009) Blood group antigen recognition by a solute- binding protein from a serotype 3 strain of Streptococcus pneumoniae. J Mol Biol. 2009 May 1;388(2):299-309.

Van Bueren AL, Higgins MA, Wang D, Burke RD, Boraston AB. (2007) Identification and structural basis of binding to host lung glycogen by streptococcal virulence factors. Nat Struct Mol Biol. 2007 Jan;14(1):76-84.

Logan SM, Chen W, Aubry A, Gidney MA, Lacelle S, St Michael F, Kuolee R, Higgins MA, Neufeld S, Cox AD. (2006) Production of a D-glycero-D-manno-heptosyltransferase mutant of Mannheimia haemolytica displaying a veterinary pathogen specific conserved LPS structure; development and functionality of antibodies to this LPS structure. Veterinary Microbiology. 116(1-3): 175-86.

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